This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in. In unblinded (open label) clinical trials, Clinical Research Site (CRS) staff and participants are all aware of the treatment/intervention assigned to each participant. The role of technology in avoiding bias in the design and execution of clinical trials Hazel Goodale, Damian McEntegartPerceptive Informatics Inc, Nottingham, United KingdomAbstract: There are many documented instances in which bias has had an adverse effect on the results of clinical trials.
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